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Interestingly, dapagliflozin may bind with FPN1 to regulate the ubiquitination and degradation of FPN1 [244]

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This cytoskeletal stabilization is thought to contribute to its observed effects on tendon and ligament healing in animal models, where organized collagen deposition and tissue strength are paramount

Last but not least, chronic low-grade inflammation is a common condition in T2DM, resulting from diabetes itself as well as from its comorbidities, which has an interdependent relationship with OS [150] and is involved in the pathogenesis of diabetes mellitus-associated ED [151]